Prospective Blinded Study of BRAF
نویسندگان
چکیده
David M. Hyman 1 , Eli L. Diamond 2 , Cecile Rose T. Vibat 3 , Latifa Hassaine 3 , Jason C. Poole 3 , Minal Patel 4 , Veronica R. Holley 5 , Goran Cabrilo 5 , Timothy T. Lu 3 , Maria E. Arcila 6 , Young Rock Chung 7 , Raajit Rampal 4 , Mario E. Lacouture 8 , Neal Rosen 9 , Funda Meric-Bernstam 5 , José Baselga 1,7 , Razelle Kurzrock 10 , Mark G. Erlander 3 , Filip Janku 5 , and Omar Abdel-Wahab 4,7
منابع مشابه
Prospective blinded study of BRAFV600E mutation detection in cell-free DNA of patients with systemic histiocytic disorders.
UNLABELLED Patients with Langerhans cell histiocytosis (LCH) and Erdheim-Chester disease (ECD) have a high frequency of BRAF(V600E) mutations and respond to RAF inhibitors. However, detection of mutations in tissue biopsies is particularly challenging in histiocytoses due to low tumor content and stromal contamination. We applied a droplet-digital PCR assay for quantitative detection of the BRA...
متن کاملMolecular Status of BRAF Mutation in Prostate Adenocarcinoma: The Analysis of 100 Cases in North-East of IRAN
Background and Objective: BRAF mutations were studied in various populations for prostate carcinoma (PC); however, mutations in BRAF gene are unusual compared to KRAS. Oncogenic activating of BRAF mutations were studied lately in almost 0%-10% of prostate cancer cases. Methods: In this retrospective study, we gathered 100 formalin-fixed ...
متن کاملA multisite blinded study for the detection of BRAF mutations in formalin-fixed, paraffin-embedded malignant melanoma
Melanoma patients with BRAF mutations respond to treatment with vemurafenib, thus creating a need for accurate testing of BRAF mutation status. We carried out a blinded study to evaluate various BRAF mutation testing methodologies in the clinical setting. Formalin-fixed, paraffin-embedded melanoma samples were macrodissected before screening for mutations using Sanger sequencing, single-strand ...
متن کاملImmunohistochemical Investigation of Mutant BRAF V600E in Common Pigmented Skin Neoplasms, Study on a Sample of Iranian Patients
Background & Objective: This study was designed for the first time for the detection of mutant BRAF V600E and its correlation with clinicophathologic features in a sample of Iranian patients with pathologically proved pigmented skin neoplasms.Methods: 82 paraffin-embedded blocks, including melanocytic nevi, malignant melanoma, Basel cell carcinoma, and sq...
متن کاملبررسی جهشهای رایج ژنهای KRAS و BRAF در بیماران مبتلا به کارسینومای بافت سنگفرشی سر و گردن
Background: Head and neck squamous cell carcinoma (HNSCC) is the malignancy of squamous cells (the epidermal layer of skin) in cavities in head and neck includes: larynx, pharynx, paranasal sinuses and oral cavity. The main goal of this research was to understand the effect of mutations in two important genes (KRAS and BRAF) in RAS/MAP kinase (EGFR) signaling pathway in tumor cells with head an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2014